The Hope to Health Research & Innovation Centre (H2H) is an interdisciplinary primary care service in Vancouver’s Downtown Eastside. H2H’s team-based approach to primary health care is based on the best evidence for service design in engaging marginalized populations. Clinical services at H2H were also planned using evidence and best-practices and refined under an ongoing quality improvement (QI) approach. Psychosocial supports offered at H2H include helping clients in areas of housing, income, social supports, and behavioural interventions.